THESIS ON SCRUB TYPHUS

The IgM ELISA with good sensitivity and specificity, ease to perform, swift results and also suitable for testing large number of specimens may be considered as good replacement for Weil-Felix test and IFA test in diagnosis of scrub typhus. Molecular diagnosis of scrub typhus: Diagnosis of scrub typhus. Therefore it is recommended to perform both pathogen and antibody based tests. Conclusion The medical fraternity needs to understand the pitfalls of currently available Weil-Felix test which is still common in India and must include tests with better performance like IgM ELISA and nested PCR in the diagnostic algorithm of scrub typhus to reduce the burden of the disease. The name scrub typhus is derived from the prevalence of the mites in areas of heavy scrub vegetation. Outbreak of scrub typhus in the North East Himalayan region-Sikkim:

Diagnosis of scrub typhus. Scrub typhus being the re-emerging zoonosis is increasingly recognised in India. Investigation of an outbreak of scrub typhus in the himalayan region of India. The mite acts as both vector and reservoir of the bacteria and efficiently transmits to its off springs through transovarian transmission. Expert Rev Anti Infect Ther. Published online Nov 1.

National Center for Biotechnology InformationU. Materials and Methods It is a prospective study which was carried out between January to June 3 years 6 monthsin a tertiary thesix hospital in Puducherry, South India.

This again emphasises the fact that Weil-Felix test is not a sensitive test for diagnosis of scrub typhus. IFA being the gold standard for serology of scrub typhus is considered as imperfect with its own limitations [ 15 ].

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

All serological tests are retrospective where diagnosis is done at the end of one week. The patients attending this hospital as both inpatients and outpatients who were clinically diagnosed to have typhus fever were thssis.

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thesis on scrub typhus

Expert Rev Anti Infect Ther. Scrub typhus being the re-emerging zoonosis is increasingly recognised in India. This is hospital based study which has its own limitations, therefore future research can be carried out with community-based study to get more data on seroprevalance of scrub typhus in Pondicherry.

Molecular diagnosis of scrub typhus: Author information Article notes Copyright and License yyphus Disclaimer. The mite acts as both scruv and reservoir of the bacteria and efficiently transmits to its off springs through transovarian transmission.

thesis on scrub typhus

An emerging infectious threat. In this study an attempt has been made to know the seropositivity in clinically suspected scrub typhus patients.

thesis on scrub typhus

Results After screening patients with acute febrile illness with a battery of diagnostic tests such as Para F for malaria, Widal tests, ICT for dengue and Ig M ELISA for leptospirosis, 63 samples reacted positively for above mentioned tests and were excluded.

The drawback of serology test is that the advantage of testing directly the presence of organism is not possible [ 14 ]. The test shows false negative results in the early stage of disease as the agglutinating antibodies can be detected only in the second week of illness [ 18 ]. The most widely performed laboratory test in India is Weil-Felix test which has low sensitivity and specificity.

Outbreak of scrub typhus in the North East Himalayan region-Sikkim: Find articles by Chanaveerappa Bammigatti. Therefore it is recommended to perform both pathogen and antibody based tests. Jpn J Infect Dis. Am J Trop Med Hyg.

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

The infection is transmitted by bite of larval stage chiggers of mites belonging to the family Trombiculidae. Recently, in India there are scrub typhus reports from Goa where the disease was not documented earlier indicating the occurrence of the disease in previously unidentified regions [ 3 ]. The blood samples were collected theesis all febrile patients who visited JIPMER hospital during the study periodand were clinically suspected as typhus fever.

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Asian J Pharm Clin Res. Find articles by Suryanarayana Bettadpura Shamanna. J Clin Diagn Res. A set of positive and negative controls were included along with every test reaction. The disease ttphus can be easily affordable with anti-rickettsial drugs, if accurate and precise diagnosis is made which can help in the speedy recovery of the patients.

Ln clinical symptoms are fever, headache, myalgia, malaise, rash and lymphadenopathy which are commonly seen in other acute febrile illness like malaria, enteric fever, leptospirosis, dengue etc. The medical fraternity needs to understand the pitfalls of currently available Weil-Felix test which is still ghesis in India and must include tests with better performance like IgM ELISA and nested PCR in the diagnostic algorithm of scrub typhus to reduce the burden of the disease.

Scrub typhus has been one of the most covert emerging and re-emerging Rickettsial infections with increasing trend in incidences of the disease worldwide including India. Scrub typhus is widespread, extending from Japan to Australia and from India to Pacific [ 2 ]. There is an upsurge in the incidence of the disease worldwide with ever-changing habitat. None Acknowledgement for financial sccrub and specific contribution only: