A comparative analysis of results of clinical trials studying the dexmedetomidine cardioprotection during surgeries with extracorporeal circulation was performed. Although not orally active, DEX shows good bioavailability when administered via various other routes like intranasal, buccal, IM than intra-venous. Prospective open-label dose-escalation pharmacokinetic-pharmacodynamic study. Dexmedetomidine is a better neuraxial adjuvant compared to clonidine for providing early onset of sensory analgesia, adequate sedation and a prolonged post-operative analgesia. This study was conducted from February to March

Fourteen patients required interventions for adverse events. In this study, we aimed to investigate the effect and mechanism of dexmedetomidine on neuronal apoptosis caused by CPB. In our study, remarkable synergistic properties of LA and dexmedetomidine have come to the fore. Esmolol is known to have no analgesic activity and no anaesthetic properties; however, it could potentiate the reduction in anaesthetic requirements and reduce postoperative analgesic use. The resulting favourable economic profile of dexmedetomidine supported the clinical use in ICU. In a model of diet-induced obesity, we compared the short-term effects of dexmedetomidine versus propofol on lung mechanics and histology, as well as biological markers of inflammation and oxidative stress modulation in obesity.

dexmedetomidine thesis topics

Dexmedetomidine infusion administered at a dosage of 0. Fourteen patients required interventions for adverse events. Our study demonstrates that DEX appears to provide better sedation, postoperative analgesia than traditional medicine midazolam during office-based artificial tooth implantation.

High-performance liquid chromatography testing was performed to determine the concentration at Days 1 through We evaluated the effect of dexmedetomidine on neurologic and histopathologic outcome from incomplete cerebral ischemia in the rat. After skinfold chamber implantation, 49 golden Syrian hamsters were randomly allocated in five groups: There are limited reports of anesthetic management of awake craniotomy in pediatric patients.


dexmedetomidine thesis topics

Both dexmedetomidine and clonidine failed to blunt the increase in hemodynamic responses heart rate and blood pressure during intubation, nasal packing, speculum insertion and extubation. Dexmedetomidine -ketamine sedation during bone marrow aspirate and biopsy in a dfxmedetomidine with duchenne muscular dystrophy. Lumbar epidural anesthesia was randomly induced as follows: Cortisol level showed no significant changes between or within groups.

Effects of dexmedetomidine on heart arrhythmia prevention in off-pump coronary artery bypass surgery: The DEX group received a loading dose of 0.

intraoperative dexmedetomidine infusion: Topics by

DEX is a potent sedative agent and also provides analgesia and anxiolytic and sympatholytic effects and has rhesis influence on respiratory physiology. One hundred and fifty American Society of Anesthesiologists physical status I or II adult patients undergoing FESS under general anesthesia were randomly allocated to three groups of 50 patients each.

Although several smaller, single-center studies suggest that dexmedetomidine use is gaining traction in the perioperative setting in children with CHD, there are limited multicenter data, with little understanding of the variation in use across age ranges, procedural complexity, and centers. To analyze the protective effect of dexmedetomidine combined with ulinastatin on cardiopulmonary function impairment caused by cardiopulmonary bypass surgery.

It provokes dose-dependent and dexmeddetomidine sympatholysis.

Choosing a Thesis Topic – SMS Anaesthesia Thesis Centre

In Group S, the haemodynamic responses were significantly attenuated. A comparative study to evaluate the efficacy of dexmedetomidine as a hypotensive agent in comparison to esmolol in Functional Endoscopic Sinus Surgery FESS.

Dexmedetomidine also increased the time Postoperative analgesia was significantly prolonged in LD Group. A year-old female patient presented with severe pain, burning and allodynia from CRPS-1 refractory to conventional therapy. Induced hypotension limits intra-operative blood loss to provide better visibility of the surgical field and diminishes the incidence of major complications during functional endoscopic sinus surgery FESS.


Hemodynamic responses to dexmedetomidine in critically injured intubated pediatric burned patients: Dexmedetomidine loading dose ranged from 0.

Administering anesthetics to the obese population requires caution because of a variety of reasons including possible interactions with the inflammatory process observed in obese patients. To evaluate the dose-response relationship of dexmedetomidine in infants with congenital heart disease postoperative from open heart surgery.

He became haemodynamically stable with adrenaline infusion.

dexmedetomidine thesis topics

None of the patients in either of the group required any additional epidural top-up dose during the surgical period. Influence of Dexmedetomidine on Toxicity of Intrathecal Ketamine Therefore, DEX appears to provide better sedation during office-based artificial tooth implantation. Venous blood samples 3. thesks

Oxidative Medicine and Cellular Longevity

Effect of dexmedetomidine on cognitive function and related cytokine contents after sevoflurane anesthesia.

Topicw to first analgesic request, postoperative morphine consumption and the incidence of side effects were also recorded. Dexmedetomidine resulted to be as effective as propofol and midazolam in maintaining the target depth of sedation in ICU patients.

The patient remained comfortable throughout the procedure and the intraoperative neuropsychological tests, brain mapping and tumour resection were successful.